Developmentally regulated H2Av buffering via dynamic sequestration to lipid droplets in Drosophila embryos
Regulating nuclear histone balance is essential for 544 million super survival, yet in early Drosophila melanogaster embryos many regulatory strategies employed in somatic cells are unavailable.Previous work had suggested that lipid droplets (LDs) buffer nuclear accumulation of the histone variant H2Av.Here, we elucidate the buffering mechanism and